ORAL CONTROLLED-RELEASE DOSAGE FORMS CONTAINING ACETAMINOPHEN

摘要

The present invention relates to oral dosage forms containing acetaminophen. More particularly, the present invention relates to oral dosage forms containing acetaminophen as a model drug, polymer base, disintegrants and lubricant, where the water-soluble additives further are contained in the said preparations. The dosage forms of the present invention are formulated to various formulations such as tablet, compressed pellet, granule and capsule. Upon exposure to the various dissolution media, the oral dosage forms of the present invention absorb water and form a gel structure, showing rapidly release of 50 % drug within a few minutes like a commercial two-layered tablet followed by the extended release thereafter. The release rate of drug is mainly governed by the swelling and erosion rate of the polymer base together with additives incorporated in matrix tablet. Unlike the two-layered commercial tablet, the new heterodisperse and single-layered HPMC matrix tablet could be easily prepared by using conventional tablet machine. The dosage forms also provide an economical and unique preparation method.