STABILIZATION OF THE PROFILE OF RELEASE OF ACTIVE SUBSTANCES FROM A FORMULATION

摘要

The invention discloses a method of a physical pre-treatment of an active substance, which modifies technologically important physical properties of the active substance so as to enable the manufacture of a formulation having a more stable release profile of the active substance over the whole shelf life of the medicine than the profile would be with the same composition, but without pre-treatment.