4-ARYL-3-HYDROXYQUINOLIN-2-ONE DERIVATIVES AS ION CHANNEL MODULATORS

摘要

There is provided novel substituted 4-aryl-3-hydroxyquinolin-2-one derivatives of the formula wherein R is hydrogen or methyl; R1, R2, R3 and R4 each are independently hydrogen, bromo, chloro or trifluoromethyl, and when R1, R3 and R4 are hydrogen, R2 is nitro; R5 is hydrogen or methyl; and R6 is bromo or chloro; or a nontoxic pharmaceutically acceptable salt thereof, which are openers of the large-conductance calcium-activated potassium channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels.