发明名称 |
METHOD FOR GENERATING HIGHLY ACTIVE HUMAN DENDRITIC CELLS FROM MONOCYTES |
摘要 |
<p>The present invention relates to a process for deriving dendritic cells from mononuclear cells in culture comprising the step of putting in contact type I IFN with said mononuclear cells. Dendritic cells suitable as cellular adjuvants in prophylactic as well as therapeutic vaccination of animal and human beings, are obtainable thereby, after a single step treatment in a brief period of time. Dendritic cells obtainable thereby, pharmaceutical compositions including them, in particular a vaccine comprising said cells as active principle, and a method of treatment of a pathology associated with the presence of an antigen in human beings, are further objects of the invention, as well as a kit for deriving said dendritic cells and a method for the ex vivo expansion of T cells using them.</p> |
申请公布号 |
EP1381674(A2) |
申请公布日期 |
2004.01.21 |
申请号 |
EP20020747298 |
申请日期 |
2002.04.29 |
申请人 |
ISTITUTO SUPERIORE DI SANITA |
发明人 |
BELARDELLI, FILIPPO;SANTINI, STEFANO, MARIA;PARLATO, STEFANIA;DI PUCCHIO, TIZIANA;LOGOZZI, MARIANTONIA;LA PENTA, CATERINA;FERRANTINI, MARIA;SANTODONATO, LAURA;D'AGOSTINO, GIUSEPPINA |
分类号 |
C12N15/09;A61K35/12;A61K35/14;A61K35/28;A61K39/00;A61K39/21;A61K39/245;A61K39/39;A61P31/00;A61P31/12;A61P35/00;C12N5/0784;C12N5/10;(IPC1-7):C12N5/08 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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