| 摘要 |
FIELD: organic synthesis. SUBSTANCE: invention provides substituted cyclic amine compounds of general formula I: (I), where Ar represents pyridine-substituted thienyl, phenyl optionally substituted by halogen, hydroxy, alkoxy, C1-C4-alkyl, phenyloxy, nitro, or phenyl; R1 represents group NHOR2, with R2 being hydrogen atom; W represents one or several hydrogen atoms; Y represents one or several substituents independently selected from group comprising hydroxy, SR3, alkoxy, NR6R7 (R6 and R7 are independently selected from hydrogen, alkyl, and pyridylalkyl), SO2R8, and COR9, or R6 and R7 together with nitrogen atom, to which they are attached, can form ring with general formula: , where Y' represents CH2,O,SO2; R3 hydrogen atom, alkyl, aryl, benzothiazolyl, pyrazinyl, and N-methylimidazolyl; R8 C1-C4-alkyl or phenyk; R9 hydrogen, alkyl, or phenyl; Z hydrogen; and n= 1; its optical isomer, diasteriomer, or enantiomer, or pharmaceutically acceptable salts thereof. Compounds I are metalloprotease inhibitors allowing them to be used for preventing and treating diseases associated with elevated activity of metalloproteases. EFFECT: extended choice of medicaments against enzyme-caused pathological conditions. 11 cl, 15 tbl, 192 ex |
