| 摘要 |
FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention describes substituted sulfonylcyanamides of the general formula (I): wherein X means , R(10-alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or CaH2a-phenyl being phenyl moiety is unsubstituted; a = 0; R(2) and R(3) independently of one another mean C1, CO-R(24), R(24)-hydrogen, OR(26), R-(26)-alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; or R(2) and R(3) independently of one another form -SOf-R(37), R(37)-alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; f = 0; Y means CR(16)R(17), SO2,, R(16)-hydrogen, R(17)-hydrogen, R(13(, R(14), R(15)- hydrogen. Invention describes pharmaceutical preparative form that is an inhibitor of sodium-dependent hydrocarbonate-chloride exchange comprising effective amount of compound of the formula (I). Compounds are inhibitors of sodium-dependent hydrocarbonate-chloride exchange. EFFECT: valuable biochemical and medicinal properties of compounds. 4 cl, 4 ex |
