发明名称 Type-1 ribosome-inactivating protein
摘要 The invention relates to a novel ribosome-binding protein derived from Bougainvillea speotabilis having a molecular weight of about 26,000 daltons by polyacrylamide gel electrophoresis under reducing and non-reducing conditions, a ph of about 9.0, and further comprising a specified amino-terminal amino acid sequence, as well as to a conjugate of said protein with a targeting ligand, such as an antibody, to form an immunotoxin. The protein and the conjugate are useful in therapy, for example in the control of tumour calls or viruses.
申请公布号 US6680296(B1) 申请公布日期 2004.01.20
申请号 US20000445160 申请日期 2000.03.10
申请人 TANOX PHARMA B.V. 发明人 STIRPE FIORENZO;BOLOGNESI ANDREA
分类号 A61K38/00;A61K38/16;A61K47/48;A61K48/00;C07K14/415;C07K19/00;C12N1/21;C12N15/29;C12N15/62;C12N15/63;(IPC1-7):A61K38/00;C07K1/00;C07K14/00 主分类号 A61K38/00
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