发明名称 |
Poliovirus replicons encoding therapeutic agents and uses thereof |
摘要 |
The invention pertains to methods of delivering a polypeptide to a cell comprising (a) contacting a cell with a replicon having a non-poliovirus nucleic acid substituted for a nucleic acid which encodes at least a portion of a protein necessary for encapsidation, the non-poliovirus nucleic acid encoding, in an expressible form, a polypeptide or fragment thereof; and (b) maintaining the cells under conditions appropriate for introduction of the replicons into the cells. The cell may be within a subject and the polypeptide may be a therapeutic agent. The methods of the invention may be used to treat diseases including central nervous system disorders, infectious diseases, and cancer.
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申请公布号 |
US6680169(B2) |
申请公布日期 |
2004.01.20 |
申请号 |
US20010835141 |
申请日期 |
2001.04.16 |
申请人 |
UNIVERSITY OF ALABAMA RESEARCH FOUNDATION |
发明人 |
MORROW CASEY D.;JACKSON CHERYL;PEDUZZI JEAN |
分类号 |
A61K38/19;A61K48/00;A61P25/00;A61P31/04;A61P35/00;C12N15/86;(IPC1-7):C12Q1/00 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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