| 摘要 |
The present invention concerns an oral morphine preparation having essential ly complete bioavailability and, for the ma- jor part of the dissolution, an essentially zero order and essentially pH independent release of morphine for a period of at least 8 hours, preferably at least 12 hours, during which period less than 100 % is dissolved. In the preparation, the morphine, in the form of an easily soluble salt, is present in combination with a buffering agent in a preparation coated with a diffusion mem- brane.
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