发明名称 |
VIRUSES AND VIRUS-LIKE PARTICLES FOR MULTIPLE ANTIGEN AND TARGET DISPLAY |
摘要 |
<p>The present invention relates to the display of antigenic or allergenic components along with a tissue-targeting component on viruses or virus-like particles. Capsid protein genes are recombinantly modified to contain the specified components then expressed within a host organism, such as yeasts, bacteria, or algae, and allowed to spontaneously form active virus particles or virus-like particles. The recombinant complexes (virus or virus-like particle) can then be purified or used in situ as a therapeutic tool for disease or allergy prevention. The expression of multivalent and multifunctional components to increase the immunogenicity of the recombinant complexes, especially on oral administration, is provided.</p> |
申请公布号 |
AU2003251604(A1) |
申请公布日期 |
2004.01.19 |
申请号 |
AU20030251604 |
申请日期 |
2003.06.25 |
申请人 |
ALLNUTT, F., C., THOMAS;KYLE, DAVID, J. |
发明人 |
F., C., THOMAS ALLNUTT;DAVID, J. KYLE |
分类号 |
A61K39/00;A61K39/21;A61K39/29;C07K14/01;C07K14/08;C07K14/16;C12N7/00;C12N7/04 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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