CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION

摘要

PURPOSE: Provided is a pharmaceutical composition which contains pseudoephedrine hydrochloride as a sustained release drug layer and pseudoephedrine hydrochloride and cetirizine hydrochloride as a rapid release drug layer. The sustained release drug layer continuously releases regardless pH changes. CONSTITUTION: A pharmaceutical composition comprises pseudoephedrine hydrochloride and cetirizine hydrochloride, which are contained in a spherical granule. The spherical granule has an inactive core, a sustained release drug layer, a sustained release coating control film, and a rapid release drug layer. The inactive core is selected from sucrose, cellulose, starch, or polyvinylpyrrolidone. The sustained release drug layer contains pseudoephedrine hydrochloride, and the rapid release drug layer contains pseudoephedrine hydrochloride and cetirizine hydrochloride.