| 摘要 |
An improved composition for controlling the release profile of an active compound through the intestinal tract comprises particles, especially pellet s, containing the active compound, which are coated with a pH dissolution dependent coating material or a polymethacrylate material, which is preferab ly pH dissolution dependent, to a certain thickness depending upon the location and rate of release of the active compound that is desired. In preferred compositions, two or more pluralities of particles, in which particles of ea ch plurality are coated with pH dissolution dependent coating material or polymethacrylate material to a different thickness to those of each other plurality, are contained within an enterically coated capsule and provide release of the active compound at various desired locations in the intestina l tract.
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