| 摘要 |
In a method of isolating osteogenic protein from bone, in which an osteogeni c protein containing fraction is extracted from bone and enriched by a sequenc e of enrichment steps selected from ultrafiltration and chromatography, the invention provides the improvement of removing higher molecular weight components from the osteogenic protein containing fraction prior to the enrichment steps. The higher molecular weight components have a molecular weight of about 100 - 300 kDa and are selected from collagen, collagen fragments, collagen aggregates and mixtures thereof.
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