NOVEL ANTIBIOTICS AGAINST VIBRIO ANGUILLARUM AND THE APPLICATIONS THEREOF IN CULTURES OF FISH, CRUSTACEANS, MOLLUSCS AND OTHER AQUACULTURE ACTIVITIES

摘要

The invention relates to novel antibiotics against Vibrio anguillarum and the applications thereof in cultures of fish, crustaceans, molluscs and other aquaculture activities. Five diketopiperazines with activity against Vibrio anguillarum have been discovered, namely compounds: cyclo(D)-proline-(D)-phenylalanine (Z59), cyclo(D)-proline-(D)-isoleucine (Z56), cyclo(D)-proline-(D)-valine (Z57), cyclo(D)-proline(D)-leucine (Z54) and cyclo(D)-hydroxyproline-(D)-phenylalanine (B717), which are obtained from two marine bacteria, Roseobacter gallaeciensis (CECT 5719) and Roseobacter sp. (CECT 5718), which are isolated from larval cultures of Pecten maximus. The addition of said compounds at a concentration of 0.5 mg/mL to cultures of fish, crustaceans and molluscs increases the survival capacity thereof with values varying between 12 % and 33 %. The inhibiting activity thereof is comparable to that of antibiotics used at present in aquaculture.