发明名称 |
RAAV VECTOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF CHOROIDAL NEOVASCULARIZATION |
摘要 |
Disclosed are methods for the use of therapeutic polypeptide-encoding polynucleotides in the creation of transformed host cells and transgenic animals is disclosed. In particular, the use of recombinant adeno-associated viral (rAAV) vector compositions comprising polynucleotide sequences that express one or more mammalian PEDF or anti-angiogenesis polypeptides is described. In particular, the invention provides gene therapy methods for the prevention, long-term treatment and/or amelioration of symptoms of a variety of conditions and disorders in a mammalian eye, including, for example blindness, loss of vision, retinal degeneration, macular degeneration, and related disorders resulting from retinal or choroidal neovascularization in affected individuals. |
申请公布号 |
WO03080648(A3) |
申请公布日期 |
2004.01.15 |
申请号 |
WO2003US08667 |
申请日期 |
2003.03.20 |
申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.;JOHNS HOPKINS UNIVERSITY;HAUSWIRTH, WILLIAM, W.;CAMPOCHIARO, PETER, A.;BERNS, KENNETH, I. |
发明人 |
HAUSWIRTH, WILLIAM, W.;CAMPOCHIARO, PETER, A.;BERNS, KENNETH, I. |
分类号 |
A61K48/00;A61P27/02;C12N15/864 |
主分类号 |
A61K48/00 |
代理机构 |
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