METHOD FOR SCREENING AN AGENT FOR IMPROVING INSULIN RESISTANCE

摘要

It is intended to disclose a method of identifying a novel substance, which promotes the interaction between PPAR.gamma. and RNA helicase and/or accelerates the expression of p68 RNA helicase to thereby promote the transcriptional induction activity of PPAR.gamma. and improve insulin resistance, and a method of screening the same. The above method is a method of screening an insulin resistance improving drug of a novel type which is different from the existing PPAR agonists promoting the transcriptional induction activity of PPAR.gamma.. It is also intended to disclose a process for producing a medicinal composition for improving insulin resistance containing, as the active ingredient, a substance which can be obtained by t he above screening method.