发明名称 |
Method for determining gene knockouts |
摘要 |
A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.
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申请公布号 |
US2004009466(A1) |
申请公布日期 |
2004.01.15 |
申请号 |
US20030616659 |
申请日期 |
2003.07.09 |
申请人 |
THE PENN STATE RESEARCH FOUNDATION |
发明人 |
MARANAS COSTAS D.;BURGARD ANTHONY P.;PHARKYA PRITI |
分类号 |
C12N15/09;C12P7/18;C12P7/46;C12P7/56;G01N33/50;G01N33/543;G06F19/00;(IPC1-7):C12Q1/00;C12Q1/68;G01N33/48 |
主分类号 |
C12N15/09 |
代理机构 |
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