DERIVATIVES OF RIFABUTINE USEFUL AS ANTIMICROBIAL AGENTS

摘要

This invention relates to new derivatives of rifabutine of general formula I, wherein R<1> is hydrogen or COR<2 >in which R<2> is independently selected from saturated or insaturated linear, branched or cyclic alkyl C1-C20; R<3> is oxygen or hydroxyl; R<4> is a nitrogen atom or N-oxide, and their acceptable salts and solvates, including hydrates. These derivatives are useful as anti-infectious agents, namely against Mycobacterium avium, and Mycobacterium tuberculosis. (I)