SUBSTITUTED 3-CYANOQUINOLINES AS MEK INHIBITORS

摘要

The invention concerns quinoline derivatives of Formula (I) wherein each of Z<1>, m, R<1>, n, R<3>, Z<2> and R<14> have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease.