COLONIC POLYP DISCRIMINIATION BY TISSUE FLOURESCENCE

摘要

A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe (160) is employed to direct ultraviolet illumination onto a tissue specimen (180) and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, about 403 nm, about 414 run, and about 431 run. The intensities of the 403 nm and 414 nm radiation are normalized using the 431 nm intensity (320). A score is determined using the ratios in a linear discriminant analysis (LDA) (330). The tissue (180) under examination is resected or not, based on the outcome of the LDA. (330)