发明名称 |
Common ligand mimics: thiazolidinediones and rhodanines |
摘要 |
The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affinity and/or selectivity of ligand binding to a receptor or receptor family through the synergistic action of the common ligand mimic and specificity ligand which compose the bi-ligand. The present invention also provides combinatorial libraries containing the common ligand mimics and bi-ligands of the invention. Further, the present invention provides methods for manufacturing the common ligand mimics and bi-ligands of the invention and methods for assaying the combinatorial libraries of the invention.
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申请公布号 |
US2004009526(A1) |
申请公布日期 |
2004.01.15 |
申请号 |
US20020081989 |
申请日期 |
2002.02.21 |
申请人 |
YU LIN;DONG QING;PIERRE FABRICE;CHANG EDCON;LANG HENGYUAN;QIN YONG;FANG YUNFENG;HANSEN MARK;PELLECCHIA MAURIZIO |
发明人 |
YU LIN;DONG QING;PIERRE FABRICE;CHANG EDCON;LANG HENGYUAN;QIN YONG;FANG YUNFENG;HANSEN MARK;PELLECCHIA MAURIZIO |
分类号 |
C07B61/00;C07D417/06;C07D417/14;C07D521/00;(IPC1-7):G01N33/53;C07D413/02;C07K5/06;G01N33/543 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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