| 发明名称 |
Indole derivatives as interleukin -4 gene expression inhibitors |
| 摘要 |
This invention discloses and claims a new class of indole derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.
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| 申请公布号 |
US2004010029(A1) |
申请公布日期 |
2004.01.15 |
| 申请号 |
US20030421511 |
申请日期 |
2003.04.23 |
| 申请人 |
MERRIMAN GREGORY H.;WEINTRAUB PHILIP M.;SABOL JEFFREY S.;DHARANIPRAGADA RAMALINGA M.;HRIB NICHOLAS J.;JURCAK JOHN G.;GROSS ALEXANDRE;WHITELEY BRIAN;MUSICK KWON YON;KLEIN JOSEPH T. |
发明人 |
MERRIMAN GREGORY H.;WEINTRAUB PHILIP M.;SABOL JEFFREY S.;DHARANIPRAGADA RAMALINGA M.;HRIB NICHOLAS J.;JURCAK JOHN G.;GROSS ALEXANDRE;WHITELEY BRIAN;MUSICK KWON YON;KLEIN JOSEPH T. |
| 分类号 |
A61K31/381;A61K31/40;A61K31/404;A61K31/405;A61K31/4436;A61K31/4439;A61K31/454;A61K31/4545;A61K31/506;A61K31/5377;A61P11/02;A61P11/06;A61P17/00;A61P27/16;A61P29/00;A61P31/04;A61P31/12;A61P35/00;A61P37/08;A61P43/00;C07D209/42;C07D401/12;C07D401/14;C07D403/12;C07D405/12;C07D405/14;C07D409/12;C07D417/12;(IPC1-7):C07D333/72 |
主分类号 |
A61K31/381 |
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