IMMUNOPOTENTIATING COMPOSITIONS

摘要

Compositions for treating cancer or infectious diseases mediated by immunopotentiation which is caused by inhibiting a immunosuppressive signal induced by PD-1, PD-L1 or PD-L2; a therapeutic method using the same; methods of screening an immunopotentiator, an anticancer substance or a substance against infectious diseases contained in these compositions as the active ingredient; a cell line to be used in these screening methods; a method of evaluating an anticancer agent; and a mammal having cancer cells transplanted therein which is to be used in the evaluation. The above compositions inhibiting the function of PD-1, PD-L1 or PD-L2 are useful in treating cancer or infectious diseases.