NANOPARTICLE POLYANION CONJUGATES AND METHODS OF USE THEREOF IN DETECTING ANALYTES
摘要
This invention provides polyanionic polymer conjugates containing non-nucleotide polyanionic polymers that are useful in detecting target analytes such as proteins or small molecules. The invention also provides nanoparticle bound to polyanionic polymer conjugates and methods of preparation and use thereof. The polyanionic polymer conjugates have the formula: L-O[PO2-O-Z-O]n-PO2-O-X wherein n ranges from 1 to 200; L represents a moiety comprising a functional group for attaching the polyanion polymer to the nanoparticle surface; Z represents a bridging group, and X represents Q, X' or -Q-X', wherein Q represents a functional group for attaching a recognition probe to the polyanion polymer, and X' represents a recognition probe.
申请公布号
WO2004004647(A2)
申请公布日期
2004.01.15
申请号
WO2003US21021
申请日期
2003.07.02
申请人
NANOSPHERE INC.;STORHOFF, JAMES, J.;LETSINGER, ROBERT, L.;HAGENOW, SUSAN, R.
发明人
STORHOFF, JAMES, J.;LETSINGER, ROBERT, L.;HAGENOW, SUSAN, R.