| 摘要 |
The invention relates to the use of fibroblast growth factor-binding protein (FGF-BP) polypeptides and functional variants of said polypeptides, or nucleic acids coding therefor and functional variants thereof, and/or a cell expressing an FGF-BP polypeptide or functional variants thereof, for the treatment, diagnosis and/or prevention of wound healing problems which are characterised by a reduced amount of FGF-BP, especially wounds associated with diabetes. The invention also relates to the use of at least one FGF-BP polypeptide according to SEQ ID NO: 1 and SEQ ID NO: 3, and/or at least one nucleic acid coding for FGF-BP, according to SEQ ID NO: 2 and SEQ ID Nr. 4, and/or antibodies or antibody fragments directed against an FGF-BP polypeptide which can be used according to the invention, or against functional variants of said polypeptide, and/or a cell expressing an FGF-BP polypeptide or functional variants thereof, for the identification of pharmacologically active substances which increase the activity or expression of FGF-BP. |
