发明名称 |
N-BENZYL-3-PHENYL-3-HETEROCYCLYL-PROPIONAMIDE COMPOUNDS AS TACHYKININ AND/ OR SEROTONIN REUPTAKE INHIBITORS |
摘要 |
<p>The present invention relates to heterocyclic derivatives of formula (1) wherein R1 represents a 5 or 6 membered heteroaryl group, in which the 5-membered heteroaryl group contains at least one heteroatom selected from oxygen, sulphur or nitrogen and the 6-membered heteroaryl group contains from 1 to 3 nitrogen atoms, or R1 represents a 4,5 or 6 membered heterocyclic group, wherein saids 5 or 6 membered heteroaryl or the 4,5 or 6 membered heterocyclic group may optionally be substituted by one to three substituents, which may be the same or different, selected from (CH2)pR6, wherein p is zero or an integer from 1 to 4 and wherein R and R2- R6 are each as defined in the description and pharmaceutically acceptable salts and solvates thereof; process for their preparation and their use in the treatment of conditions mediated by tachykinins and/or by selective inhibition of serotonin reuptake transporter protein.</p> |
申请公布号 |
WO2004005255(A1) |
申请公布日期 |
2004.01.15 |
申请号 |
WO2003EP07126 |
申请日期 |
2003.07.02 |
申请人 |
GLAXO GROUP LIMITED;ALVARO, GIUSEPPE;CARDULLO, FRANCESCA;D'ADAMO, LUCILLA;PIGA, ELISABETTA;SERI, CATIA |
发明人 |
ALVARO, GIUSEPPE;CARDULLO, FRANCESCA;D'ADAMO, LUCILLA;PIGA, ELISABETTA;SERI, CATIA |
分类号 |
A61K31/40;A61K31/44;A61K31/445;A61K31/535;A61P1/08;A61P25/00;A61P29/00;C07D207/08;C07D207/20;C07D211/34;C07D211/38;C07D211/70;C07D213/56;C07D265/30;(IPC1-7):C07D211/14;C07D213/16;C07D207/06 |
主分类号 |
A61K31/40 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|