METHOD OF ENDOVASCULAR BRAIN MAPPING

摘要

Disclosed are the following strategies for endovascularly mapping the brain with a chemical agent capable of staining the preselected region of the brain to a color visibly contrasting with non-stained portions of the brain and of passing through the blood-brain barrier to the preselected region of the brain: 1) Passive transport: (a) pro-drug, (b) Modification of mapping agent to mimic molecules that readily cross the BBB (e.g., amino acid, glucose, etc.); 2) Active transport; 3) Receptor-mediated transport (e.g., antibody mediated); 4) Blood brain barrier (BBB) manipulation; 5) Emulsification of agent (such as beta-carotene, organic dye, etc.) to stain capillary endothelium; 6) Embolization of brain capillaries; 7) Grafted-nanoparticle systems for brain delivery of mapping agent.