摘要 |
The invention relates to pyrazoline derivatives of formula (I), wherein R1 represents hydrogen, methyl, fluoromethyl, difluoromethyl, trifluoromethyl,carboxylic acid, alkyl carboxylate with less than 1 to 4 carbon atoms, carboxamide or cyan; R2 represents hydrogen or methyl; R3, R4, R7 and R8 independently represent hydrogen, chlorine, fluorine, methyl, trifluoromethyl or methoxy; R5 and R6 independently represent hydrogen, chlorine, fluorine, methyl, trifluoromethyl, methoxy, trifluoromethoxy, methylsulfpnyl, aminosulfonyl or acetylaminosulfonyl provided that one of the substituents R5 or R6 is a methylsulfonyl, aminosulfonyl or acetylaminosulfonyl group and provided that if R1 is methyl then R2 is hydrogen or methyl, R3 and R8 are independently hydrogen, chlorine, fluorine, methyl or trifluoromethyl, R4 is hydrogen, fluorine, methyl, trifluoromethyl or methoxy, R5 is fluorine, trifluoromethyl, trifluoromethoxy, methylsulfonyl, aminosulfonyl or acetylaminosulfonyl, R6 is hydrogen, chlorine, fluorine, methyl, trifluoromethyl, methoxy, trifluoromethoxy, methylsulfonyl, aminosulfonyl or acetylaminosulfonyl, provided that one of the substituents R5 or R6 is a methylsulfonyl, arninosulfonyl or acetylaminosulfonyl group and R7 represents a hydrogen atom, chlorine, fluorine, a methyl, trifluoromethyl or methoxy group. Said derivatives are useful for the prevention or treatment of PROLIFERATIVE cell diseases. (I)
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