Oxazolo, thiazolo and selenazolo [4,5-c]naphthyridine-4-amines and analogs thereof

摘要

The present invention refers to a compound of the formula I: <CHEM> wherein: R1 is selected from the group consisting of oxygen, sulfur and selenium; R2 is selected from the group consisting of hydrogen; alkyl; alkyl-OH; haloalkyl; alkenyl; alkyl-X-alkyl; alkyl-X-alkenyl; alkenyl-X-alkyl; alkenyl-X-alkenyl; alkyl-N(R5)2; alkyl-N3; alkyl-O-C(O)-N(R5)2; heterocyclyl; alkyl-X-heterocyclyl; alkenyl-X-heterocyclyl; aryl; alkyl-X-aryl; alkenyl-X-aryl; heteroaryl; alkyl-X-heteroaryl; and alkenyl-X-heteroaryl; R3 and R4 taken together form a fused pyridine ring that may be substituted or unsubstituted; X is selected from the group consisting of-O-, -S-, -NR5-, -C(O)-, -C(O)O-, -OC(O)-, and a bond; and each R5 is independently H or C1-8alkyl; or a pharmaceutically acceptable salt thereof.