REMEDIES FOR VESICAL STIMULATION IN ASSOCIATION WITH PROSTATAUXE

摘要

The present invention provides a therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia comprising, as an active ingredient, a tricyclic compound represented by formula (I): <CHEM> Äwherein R<1> represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy or halogen; X<1>-X<2>-X<3> represents CR<5>=CR<6>-CR<7>=CR<8>, N(O)m=CR<6>-CR<7>=CR<8>, CR<5>=CR<6>-N(O)m=CR<8>, CR<5>=CR<6>-CR<7>=N(O)m, CR<5>=CR<6>-O, CR<5>=CR<6>-S, O-CR<7>=CR<8>, S-CR<7>=CR<8> or O-CR<7>=N; Y represents -CH2S-, -CH2SO-, -CH2SO2-, -CH2O-, -CH=CH-, - (CH2)p-, -SCH2-, -SOCH2-, -SO2CH2- or -OCH2-; and R<2> represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkoxy, amino, mono(substituted or unsubstituted lower alkyl)-substituted amino, di(substituted or unsubstituted lower alkyl)-substituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkylamino, substituted or unsubstituted arylamino or a substituted or unsubstituted heteroalicyclic groupÜ or a pharmaceutically acceptable salt thereof.