发明名称 |
Anthranilic acid amides, process of their preparation and their use as antiarrhythmic agents and pharmaceutical compositions in which the amides are comprised |
摘要 |
<p>The present invention is related to anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and pharmaceutical preparations containing them. The compounds act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. The compounds are therefore suitable for use as novel antiarrhythmic agents for the treatment and prophylaxis of atrial arrhythmias (e.g., atrial fibrillation (AF) or atrial flutter).</p> |
申请公布号 |
CZ20032921(A3) |
申请公布日期 |
2004.01.14 |
申请号 |
CZ20030002921 |
申请日期 |
2002.04.13 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
BRENDEL JOACHIM;PIRARD BERNARD;PEUKERT STEFAN;KLEEMANN HEINZ-WERNER;HEMMERLE HORST |
分类号 |
C07D233/61;A61K31/18;A61K31/341;A61K31/40;A61K31/4045;A61K31/415;A61K31/417;A61K31/4184;A61K31/426;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/47;A61K45/00;A61P9/06;C07C311/08;C07C311/21;C07C311/29;C07C311/44;C07D207/32;C07D207/335;C07D209/14;C07D213/40;C07D213/64;C07D215/12;C07D231/12;C07D231/16;C07D233/54;C07D233/64;C07D235/10;C07D235/14;C07D277/28;C07D277/30;C07D307/14;C07D307/52;C07D405/12;C07D521/00;(IPC1-7):C07C311/21 |
主分类号 |
C07D233/61 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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