发明名称 |
Process for preparing (3-cyano-1H-indol-7-yl)[4-(4-fluoro phenethyl)-piperazin-1-yl]methanone and a salt thereof |
摘要 |
<p>The present invention relates to a process for the preparation of (3-cyano-1H-indol-7-yl)[4-(4-fluorophenethyl)piperazin-1-yl]-methanone and salts thereof, characterised in that an indole ester of the formula II in which R is as defined in Claim 1, is converter into 3-cyano-1H-indole-7-carboxylic acid via steps (1) to (4) according to Claim 1, and this is reacted with 1-[2-(4-fluorophenyl)ethyl]piperazine of salts thereof to give the product.</p> |
申请公布号 |
CZ20032202(A3) |
申请公布日期 |
2004.01.14 |
申请号 |
CZ20030002202 |
申请日期 |
2001.12.21 |
申请人 |
MERCK PATENT GMBH |
发明人 |
CRASSIER HELENE;ECKERT UWE;BOTTCHER HENNING;BATHE ANDREAS;EMMERT STEFFEN |
分类号 |
A61K31/496;A61P1/14;A61P7/02;A61P9/00;A61P9/06;A61P25/00;A61P25/04;A61P25/20;A61P25/22;A61P25/30;A61P27/06;A61P39/02;A61P43/00;C07D209/14;C07D209/30;C07D209/42;C07D211/78;(IPC1-7):C07D403/06;C07D295/04 |
主分类号 |
A61K31/496 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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