发明名称 |
COMPOUNDS WITH IMPROVED INDUCTIVE EFFECT ON CARTILAGE AND BONES |
摘要 |
<p>The present invention concerns a bioactive implant material having a cartilage-inducing and/or bone-inducing activity composed of two components A and B, of which A is a bone-inducing and/or cartilage-inducing protein or protein mixture and preferably one or several proteins from the TGF-beta superfamily, preferably MP52 or a DNA sequence coding therefor and B is a carrier matrix composed of calcium phosphate ceramics with an interconnecting microporosity which already alone has bone-inducing properties. The invention additionally concerns the production of these compounds and their use for the treatment of diseases which affect cartilage and/or bones as well as to treat damage to cartilage and/or bone tissue.</p> |
申请公布号 |
EP0942758(B1) |
申请公布日期 |
2004.01.14 |
申请号 |
EP19970951919 |
申请日期 |
1997.11.19 |
申请人 |
BIOPHARMGESELLSCHAFT ZUR BIOTECHNOLOGISCHENENTWICKLUNG VON PHARMAKA MBH |
发明人 |
PAULISTA, MICHAEL;POHL, JENS;PABST, JOACHIM;HEIDE, HELMUT |
分类号 |
C12N15/09;A61K38/00;A61K38/18;A61L27/00;A61L27/22;A61L27/42;C07K14/495;C07K14/51;C07K19/00;(IPC1-7):A61L27/00;A61P19/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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