PHOSPHONIC DIESTER DERIVATIVES

摘要

A phosphonic diester derivative represented by general formula (I) and useful as remedies for hyperlipidemia, hypertension, diabetes, and so forth. In said formula, A represents oxygen or sulfer; R1, R2, R9 and R10 represent each independently hydrogen, lower alkoxy, nitro, lower alkyl, halogenated lower alkyl or halogen; R3 represents phenyl, -B-R6 (wherein B represents oxygen or sulfur; and R6 represents hydrogen, lower alkyl, cycloalkyl, phenyl, phenylated lower alkyl wherein the phenyl may be halogenated, phenoxylated lower alkyl, lower-alkoxy carbonyl-substituted lower alkyl, carboxylated lower alkyl or lower alkenyl) or -NR7R8 (wherein R7 and R8 represent each independently hydrogen, lower alkyl, amino or cycloalkyl, or R7 and R8 are combined together to form lower alkylene); and R4 and R5 represent each independently hydrogen or lower alkyl.