| 摘要 |
A carbohydrate peptide conjugate containing:(i) a carrier containing a dendrimeric poly-lysine enabling multiple epitopes to be covalently attached thereto,(ii) at least one peptide containing one T epitope or several identical or different T-epitopes,(iii) at least one carbohydrate moiety which is tumor antigen, or a derivative thereof, containing a B epitope, provided it is not a sialoside, or several identical or different epitopes, wherein said conjugate containing at least 3-lysines and up to 15 lysine covalently linked to one another, and wherein:(a) to the NH2 and of at least two lysine residues is bound at least one carbohydrate residue being not a sialoside, optionally substituted and containing an epitope and wherein the peptide containing one T epitope is covalently bound to the end of said carbohydrate which induces immune responses.
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