发明名称 |
Prodrug activation using catalytic antibodies |
摘要 |
The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.
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申请公布号 |
US6677435(B2) |
申请公布日期 |
2004.01.13 |
申请号 |
US20010883758 |
申请日期 |
2001.06.18 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
BARBAS, III CARLOS F.;SHABAT DORON;RADER CHRISTOPH;LIST BENJAMIN;LERNER RICHARD A. |
分类号 |
A61K31/365;A61K31/704;A61K38/00;A61K39/395;A61P31/12;A61P35/00;C07D493/04;C07H15/252;(IPC1-7):C07K16/00 |
主分类号 |
A61K31/365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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