摘要 |
The invention relates to a process for the enantioselective preparation of glycide ester (I) by(a) dihydroxylation of a corresponding 3-phenyl cinnamate (II) by osmium (VIII) oxide catalysis in the presence of a Sharpless ligand and an oxidizing agent to form the dihydroxy ester (III),(b) selective conversion of the hydroxy function in position 2 of the dihydroxy ester (III) to a leaving group,(c) intramolecular substitution of the leaving group through the hydroxy function in position 3 to form the glycide ester (I),in whichR1 denotes C1-C10 alkyl, aryl, or arylalkyl, which may be substituted,R2 denotes C1-C10 alkyl, aryl, arylalkyl, halogen, C1-C10 alkoxy, acyloxy, or amide, which may be substituted, andn is 0 to 5.
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