发明名称 |
Ligand-targeted emulsions carrying bioactive agents |
摘要 |
A composition for use in delivering a bioactive agent to targeted tissues or cells comprises: (a) a site-specific targeting ligand; (b) a lipid encapsulated oil in water emulsion; and (c) a bioactive agent in or on the surface of the outer monolayer of the emulsion; the ligand being conjugated directly or indirectly to the emulsion and the composition providing facilitated delivery of the bioactive agent through prolonged association and increased contact of the ligand-bound lipid encapsulated emulsion particles with the lipid bilayer of the target tissues or cells. The composition may also comprise a lipid encapsulated oil in water emulsion and a combination site-specific targeting ligand/bioactive agent. Methods for improved delivery of a bioactive agent to targeted tissues or cells are also disclosed.
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申请公布号 |
US6676963(B1) |
申请公布日期 |
2004.01.13 |
申请号 |
US20000697796 |
申请日期 |
2000.10.27 |
申请人 |
BARNES-JEWISH HOSPITAL |
发明人 |
LANZA GREGORY M.;WICKLINE SAMUEL A. |
分类号 |
A61K9/107;A61K47/48;(IPC1-7):A61K9/127 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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