发明名称 |
Mutations of the C-terminal portion of TGF-beta superfamily proteins |
摘要 |
The invention provides modified proteins and DNAs of the TGF-beta superfamily including modified morphogenic proteins. The proteins of the present invention display altered biological or biochemical attributes. Specifically, the modified proteins are designed through substitutions of amino acids in the finger 2 sub-domain or exchanges of all or part of the finger 2 sub-domain of one TGF-beta superfamily member with the finger 2 sub-domain of another TGF-beta superfamily member.
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申请公布号 |
US6677432(B1) |
申请公布日期 |
2004.01.13 |
申请号 |
US19990374958 |
申请日期 |
1999.08.16 |
申请人 |
STRYKER CORPORATION |
发明人 |
OPPERMANN HERMANN;TAI MEI-SHENG;MCCARTNEY JOHN |
分类号 |
C12N15/09;A61K38/00;A61K38/22;A61P43/00;C07K14/47;C07K14/495;C07K14/51;C07K19/00;C12N15/12;C12N15/62;C12P21/02;(IPC1-7):C07K14/00;C12N15/00;L12N15/62 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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