| 摘要 |
Dipeptide nitrile Cathepsin K inhibitors of formula I, and pharmaceutically acceptable salts or esters thereof In which R<SUB>1 </SUB>and R<SUB>2 </SUB>are independently H or C<SUB>1</SUB>-C<SUB>7</SUB>lower alkyl, or R<SUB>1 </SUB>and R<SUB>2 </SUB>together with the carbon atom to which they are attached form a C<SUB>3</SUB>-C<SUB>8</SUB>cycloalkyl ring, and Het is an optionally substituted nitrogen-containing heterocyclic substituent, are provided, useful e.g. for therapeutic or prophylactic treatment of a disease or medical condition in which cathepsin K is implicated. |
