| 摘要 |
FIELD: organic chemistry, veterinary science, medicine, oncology, biochemistry. SUBSTANCE: invention relates to inhibitors of cyclooxygenase-2 of the formula (I) and (II) that are useful in treatment and/or prophylaxis of tumors, tumor-associated disorders and tumor metastasis and for inhibiting tumors growth in mammals. The proposed active agent elicits low level of adverse effects, low toxicity level but high activity with respect to prophylaxis and treatment of tumors and tumor-associated disorders. EFFECT: valuable medicinal properties of agent. 11 cl, 7 tbl, 9 ex |
