| 摘要 |
The present invention provide for methods of inhibiting cancer cell growth using IGFBP-3 polypeptides and expression constructs coding therefor. In a particular aspect, the invention provides adenoviral constructs expressing IGFBP-3, and their use to inhibit non-small cell lung cancer. In addition, IGFBP-3 expression can be diagnostic of cancer development and progression. Methods for assessing IGFBP-3 expression, for example using promoter methylation assays, are described.
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