| 摘要 |
PROBLEM TO BE SOLVED: To provide an antiseptic composition for ophthalmic preparation free from stimulation to eyes, safely applicable also to eyes causing dry eye, eye strain, etc., or eyes having trouble in ocular mucous membrane and to provide an ophthalmic composition free from an antiseptic agent. SOLUTION: The antiseptic composition comprises (A) 0.5-5.0 wt.% trometamol and (B) an weak acid having 2-7 pKa at 25°C, e.g. boric acid, phosphoric acid, acetic acid, maleic acid, phthalic acid or amino acid at a weight ratio (A)/(B) of (1/5) to (5/1) and has pH 5-7.5. The ophthalmic composition comprises the antiseptic composition and≤0.0005 wt.% stimulating antiseptic agent or preferably does not contain the stimulating antiseptic agent. COPYRIGHT: (C)2004,JPO
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