Monoclonal and polyclonal antibodies recognizing coagulase-negative staphylococcal proteins

摘要

Monoclonal and polyclonal antibodies are provided which recognize and bind to the SdrG protein of S. epidermidis, and more particularly to antibodies which recognize specific domains of the SdrG protein, namely the SdrG N1N2N3 protein (amino acids 50-597), the SdrG N2N3 protein (amino acids 273-597) and a truncated version of N2N3 identified as SdrG TR2 (amino acids 273-577). The antibodies of the invention, as well as pharmaceutical compositions incorporating these antibodies, are particularly useful in treating or preventing infections caused by coagulase-negative staphylococci