发明名称 |
Use of HMG fragments as anti-inflammatory agents |
摘要 |
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMG A box, and an antibody preparation that specifically binds to a vertebrate HMG B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.
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申请公布号 |
US2004005316(A1) |
申请公布日期 |
2004.01.08 |
申请号 |
US20030456949 |
申请日期 |
2003.06.06 |
申请人 |
NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE |
发明人 |
TRACEY KEVIN J.;YANG HUAN |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P1/02;A61P1/04;A61P3/04;A61P3/10;A61P5/14;A61P7/00;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P13/00;A61P13/08;A61P15/02;A61P17/16;A61P19/02;A61P21/04;A61P25/00;A61P25/04;A61P25/28;A61P27/02;A61P29/00;A61P31/04;A61P31/12;A61P31/16;A61P31/18;A61P31/20;A61P31/22;A61P33/06;A61P37/00;A61P37/06;A61P37/08;A61P43/00;C07K14/00;C07K14/47;C07K16/00;C07K16/18;C12N5/06;C12N5/10;C12P21/06;C12Q1/02;(IPC1-7):A61K39/395 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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