IMMUNOLIPOSOME CONJUGATED WITH ANTI-UPA ANTIBODY

摘要

The present invention relates to an immunoliposome conjugated with a specific monoclonal anti-uPA antibody, which is a selective drug delivery system targeted to such cells overexpressing uPA (urokinase type plasminogen activator) as cancer cells or endothelial cells participating in angiogenesis in cancer tissue. The immunoliposome conjugated with an anti-uPA monoclonal antibody which is secreted from a fused cell of myeloma cells and spleen cells of mouse immunized with human uPA is one of the possible candidates of efficient drug delivery system to uPA over-expressing cancer cells that may show malignant behavior, such as local invasion and metastasis. Anticancer drugs encapsulated in the anti-uPA immunoliposome can not only directly kill tumor cells but also indirectly kill tumor cells by the interruption of oxygen and nutrients to tumor mass, which can be achived by killing the endothelial cells involved in angiogenesis.