发明名称 GLYCOALKALOID COMPOSITIONS AND VARIOUS USES THEREOF
摘要 A composition comprising at least two glycoalkaloids of formula (I): wherein : either one or both of the dotted lines represents a double bond, and the oth er a single bond, or both represent single bonds; A: represents a radical selected from the following radicals of general formulae (II) to (V): or eac h of R1 is a radical separately selected from the group consisting of hydrogen , amino, oxo and OR4; each of R2 is a radical separately selected from the gro up consisting of hydrogen, amino and OR4; each of R3 is a radical separately selected from the group consisting of hydrogen, carbohydrate and a carbohydrate derivative; "X" is a radical selected from the group comprising - CH2-, -0- and -NH2-; and wherein the compound includes at least one R4 group that is a carbohydrate or a derivative thereof selected from the group comprising glyceric aldehyde, glycerose, erythrose, threose, ribose, arabinose, xylose, lyxose, altrose, allose, gulose, mannose, glucose, idose, galactose, talose, rhamnose, dihydroxyactone, erythrulose, ribulose, xylulos e, psicose, fructose, sorbose, tagatose, and other hexoses, heptoses, octoses, nanoses, decoses, deoxysugars with branched chains, (e.g. apiose, hamamelose , streptose, cordycepose, mycarose and cladinose), compounds wherein the aldehyde, ketone or hydroxyl groups have been substituted (e.g. N-acetyl, acetyl, methyl, replacement of CH20H), sugar alcohols, sugar acids, benzimidazoles, the enol salts of the carbohydrates, saccharinic acids, suga r phosphates; and wherein the ratio of said glycoalkaloids is between 6:1 and 1:6 and on the proviso that when the glycoalkaloids are solamargine and solasonine and they are present in a 1:1 ratio the solamargine and solasonin e are isolated.
申请公布号 CA2489675(A1) 申请公布日期 2004.01.08
申请号 CA20032489675 申请日期 2003.06.24
申请人 SOLBEC PHARMACEUTICALS LIMITED 发明人 CARTER, STEPHEN JOHN;WILLIAMS, ELIZABETH
分类号 A61K31/706;A61P15/04;A61P15/18;A61P17/12;A61P31/00;A61P35/00;G01N33/58;(IPC1-7):A61K31/706 主分类号 A61K31/706
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