| 摘要 |
Microfluidic devices and methods for metering discrete plugs of fluid are provided. The microfluidic devices include an actuating channel, a metering channel and a deformable membrane disposed therebetween. The metering channel is in fluid communication with a fluid source, but is otherwise closed. The pressure in the actuating channel is varied to deform the deformable membrane. The volume of the metering channel varies in proportion with the deformation of the deformable membrane, creating a pressure differential between the metering channel and the fluid source. The pressure differential causes fluid from the fluid source to be drawn into or expelled from the metering channel.
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