发明名称 |
USE OF AT LEAST ONE DOLLAR G(A)62 CASEIN PEPTIDE WITH ANGIOTENSIN I CONVERTING ENZYME INHIBITING ACTIVITY FOR PREPARING MEDICINES, FOOD PRODUCTS AND FOOD COMPLEMENTS |
摘要 |
The invention concerns the use for preparing anti-hypertensive medicines useful for treating or preventing hypertension, of one or more peptides having ACE inhibiting activity with IC50 values not more than 60 mu M, selected among peptide groups having the following amino acid sequences: Thr-Val-Tyr (SEQ ID NO: 1) Asn-Met-Ala-lle-Asn-Pro-Ser-Lys (SEQ ID NO: 2) Phe-Ala-Leu-Pro-Gln-Tyr (SEQ ID NO: 3) Phe-Pro-Gln-Tyr-Leu-Gln-Tyr (SEQ ID NO: 4) Phe-Ala-Leu-Pro-Gln-Tyr-Leu-Lys (SEQ ID NO: 5) Asn-Met-Ala-lle-Asn-Pro (SEQ ID NO: 6) Phe-Ala-Leu-Pro (SEQ ID NO: 7). The invention also concerns a pharmaceutical composition containing, as active principle, an efficient amount of one or more said peptides, in combination with a pharmaceutically acceptable carrier. The invention further concerns a food product, in particular for supplementing the diet of persons liable to hypertension or wishing to prevent its occurrence, containing an efficient amount of one or more said peptides, in combination with food supports, in particular proteins, lipids or carbohydrates. Such a food product may also include at least one of the peptides having the following amino acid sequences: Ala-Leu-Asn-Glu-lle-Asn-Gln-Phe-Tyr-Gln-Lys (SEQ ID NO: 8) Ala-Leu-Asn-Glu-lle-Asn-Gln-Phe-Tyr (SEQ ID NO: 9) Tyr-Leu (SEQ ID NO: 10). |
申请公布号 |
WO2004002509(A2) |
申请公布日期 |
2004.01.08 |
申请号 |
WO2003FR01945 |
申请日期 |
2003.06.24 |
申请人 |
INGREDIA;TAUZIN, JEROME;MICLO, LAURENT;LEFRANC, CATHERINE;BOUDIER, JEAN-FRANCOIS;GAILLARD, JEAN-LUC |
发明人 |
TAUZIN, JEROME;MICLO, LAURENT;LEFRANC, CATHERINE;BOUDIER, JEAN-FRANCOIS;GAILLARD, JEAN-LUC |
分类号 |
A23L1/305;A61K38/05;A61K38/06;A61K38/07;A61K38/08;A61K38/55;A61P9/12;A61P43/00;C07K5/065;C07K5/083;C07K5/107;C07K7/04;C12N9/99 |
主分类号 |
A23L1/305 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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