NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE

摘要

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are usef ul for the treatment of RNA-dependent RNA viral infection. They are particularl y useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibito rs of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active agains t RNA-dependent RNA viral infection, in particular HCV infection. Also disclos ed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA- dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.